Alexander Disease

General

• Megalencephaly

Airway

• Copious oral secretions
• Large head

Gastrointestinal

• GERD

Neurological

• Seizures
• Progressive spasticity & dementia
• Hydrocephalus

Considerations

• Aspiration risk
• Positioning challenges
• Anticonvulsants may affect drug metabolism
• Avoid phenothiazines, butyrophenones, metoclopramide, dopaminergic blockers which may affect movement disorders

Links

• Adrenoleukodystrophy
• Metachromatic Leukodystrophy
• Krabbe disease
• Canavan disease
• Pelizaeus-Merzbacher disease